Article
GSTM1, GSTT1, and GSTP1 polymorphisms and risk of advanced colorectal adenoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2005
Moore Lee E, Huang Wen-Yi, Chatterjee Nilanjan, Gunter Marc, Chanock Stephen, Yeager Meredith, Welch Bob, Pinsky Paul, Weissfeld Joel, Hayes Richard B
Abstract excerpt
Cigarette smoking is a risk factor for colon adenoma. The glutathione S-transferase enzymes are involved in the detoxification of carcinogenic compounds including those found in tobacco smoke, and thus, may be important modifiers of individual risk of developing this disease. We examined the prevalence of GSTM1 and GSTT1 gene deletions, and two GSTP1 polymorphisms in 772 cases with advanced colorectal adenomas...
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