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Article

Cigarette smoking, N-acetyltransferase genes and the risk of advanced colorectal adenoma.

Pharmacogenomics - 1 Sept 2006

Moslehi Roxana, Chatterjee Nilanjan, Church Timothy R, Chen Jinbo, Yeager Meredith, Weissfeld Joel, Hein David W, Hayes Richard B

Abstract excerpt

BACKGROUND: Cigarette use is associated with greater risk for colorectal adenoma, a colorectal cancer precursor. N-acetyltransferases, NAT1 and NAT2, are important enzymes involved in the metabolism of aromatic amine carcinogens present in cigarette smoke. Our interest is in the polymorphisms within the NAT1 and NAT2 genes that influence the tobacco-colorectal tumor relationship by impacting on the metabolic...

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Source

Identifiers

PMID: 16981843
DOI: 10.2217/14622416.7.6.819

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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