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Article

Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2008

Peters Ulrike, Chatterjee Nilanjan, Hayes Richard B, Schoen Robert E, Wang Yinghui, Chanock Stephen J, Foster Charles B

Abstract excerpt

BACKGROUND: Epidemiologic and animal studies provide evidence for a chemopreventive effect of selenium on colorectal cancer, which may be mediated by the antioxidative and anti-inflammatory properties of selenoenzymes. We therefore investigated whether genetic variants in selenoenzymes abundantly expressed in the colon are associated with advanced colorectal adenoma, a cancer precursor. METHODS: Cases with a...

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Source

Identifiers

PMID: 18483336
DOI: 10.1158/1055-9965.EPI-07-2947

Genes

TXNRD1
GPX1
GPX2
GPX3
GPX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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