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Glutathione S-transferase (GST) gene polymorphisms, cigarette smoking and colorectal cancer risk among Chinese in Singapore.

Carcinogenesis - 1 Oct 2011

Koh Woon-Puay, Nelson Heather H, Yuan Jian-Min, Van den Berg David, Jin Aizhen, Wang Renwei, Yu Mimi C

Abstract excerpt

Cigarette smoking is a risk factor for colorectal cancer. Putative colorectal procarcinogens in tobacco smoke include polycyclic aromatic hydrocarbons and heterocyclic aromatic amines that are known substrates of glutathione S-transferases (GSTs). This study examined the influence of functional GST gene polymorphisms on the smoking-colorectal cancer association in a population known to be minimally exposed to...

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Identifiers

PMID: 21803734
DOI: 10.1093/carcin/bgr175
PMCID: PMC3179426

Genes

GSTM1
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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