Article
Glutathione transferase (GSTM1) null genotype, smoking, and prevalence of colorectal adenomas.
Cancer research - 15 Mar 1995
Lin H J, Probst-Hensch N M, Ingles S A, Han C Y, Lin B K, Lee D B, Frankl H D, Lee E R, Longnecker M P, Haile R W
Abstract excerpt
Colorectal cancer is caused by environmental exposures and genetic predisposition. However, little is known of hereditary factors that influence development of common, non-Mendelian forms of this cancer. Interactions among carcinogen exposure, hereditary variants of enzymes involved in carcinogen metabolism, and other host factors may play a role. Genetic polymorphisms of carcinogen metabolism, such as the...
Topics
- Adenoma
- Aged
- Case-Control Studies
- Colorectal Neoplasms
- Female
- Genotype
- Glutathione Transferase
- Humans
- Male
- Middle Aged
- Prevalence
- Smoking