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Article

Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk.

American journal of epidemiology - 1 Nov 2010

Cleary Sean P, Cotterchio Michelle, Shi Ellen, Gallinger Steven, Harper Patricia

Abstract excerpt

The risk of colorectal cancer associated with smoking is unclear and may be influenced by genetic variation in enzymes that metabolize cigarette carcinogens. The authors examined the colorectal cancer risk associated with smoking and 26 variants in carcinogen metabolism genes in 1,174 colorectal cancer cases and 1,293 population-based controls recruited in Canada by the Ontario Familial Colorectal Cancer Registry...

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Source

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Identifiers

PMID: 20937634
DOI: 10.1093/aje/kwq245
PMCID: PMC2984254

Genes

NAT1
GSTM1
NAT2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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