Article
Glutathione S-transferase polymorphisms and risk of colorectal adenomas.
Cancer letters - 26 Feb 2001
Inoue H, Kiyohara C, Shinomiya S, Marugame T, Tsuji E, Handa K, Hayabuchi H, Eguchi H, Fukushima Y, Kono S
Abstract excerpt
Glutathione S-transferases (GSTs) are a superfamily of detoxification enzymes that may play an important role in human carcinogenesis. While the genetic polymorphisms GSTM1 and GSTT1 have drawn particular interest in relation to cancer susceptibility, previous studies of colorectal cancer are inconsistent regarding their role. We examined the relation between GSTM1 and GSTT1 genotypes combined and colorectal...
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