Phosphorylation of IcsA by cAMP-dependent protein kinase and its effect on intracellular spread of Shigella flexneri.

doi:10.1111/j.1365-2958.1992.tb01534.x

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Article

Phosphorylation of IcsA by cAMP-dependent protein kinase and its effect on intracellular spread of Shigella flexneri.

Molecular microbiology - 1 Apr 1992

d'Hauteville H, Sansonetti P J

Abstract excerpt

Shigella flexneri, a Gram-negative bacillus belonging to the family Enterobacteriaceae, causes bacillary dysentery in humans by invading colonic epithelial cells. Processes by which epithelial cells, which are not professional phagocytes, may limit the spread of the invading microorganisms are po...

Topics

Amino Acid Sequence
Bacterial Proteins
Base Sequence
Cloning, Molecular
DNA, Bacterial
DNA-Binding Proteins
HeLa Cells
Humans
Molecular Sequence Data
Mutagenesis, Site-Directed
Phenotype
Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinases

Restriction Mapping

Shigella flexneri

Substrate Specificity

Transcription Factors

Virulence

Source

Open in PubMed

Identifiers

PMID: 1602963
DOI: 10.1111/j.1365-2958.1992.tb01534.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1602963-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Phosphorylation of IcsA by cAMP-dependent protein kinase and its effect on intracellular spread of Shigella flexneri.PMID 1602963Read ↗

Disruption of IcsP, the major Shigella protease that cleaves IcsA, accelerates actin-based motility.Semantic proximity Read ↗

icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread.Semantic proximity Read ↗

Shigella flexneri cell-to-cell spread, and growth and inflammation in mice, is limited by the outer membrane protease IcsP.Semantic proximity Read ↗

Identification of Shigella flexneri IcsA residues affecting interaction with N-WASP, and evidence for IcsA-IcsA co-operative interaction.Semantic proximity Read ↗

The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function.Semantic proximity Read ↗

IcsA surface presentation in Shigella flexneri requires the periplasmic chaperones DegP, Skp, and SurA.Semantic proximity Read ↗

<i>Shigella flexneri</i> disruption of host cell-cell tension promotes intercellular spreadSemantic proximity Read ↗

Modulation of an outer membrane protease contributes to the virulence defect of Shigella flexneri strains carrying a mutation in the virK locus.Semantic proximity Read ↗

dksA is required for intercellular spread of Shigella flexneri via an RpoS-independent mechanism.Semantic proximity Read ↗

Genetic and Molecular Basis of Epithelial Cell Invasion by Shigella SpeciesSemantic proximity Read ↗

Phosphorylation of the virulence regulator SarA modulates its ability to bind DNA in<i>Staphylococcus aureus</i>Semantic proximity Read ↗

Myosin IIA is essential for Shigella flexneri cell-to-cell spread.Semantic proximity Read ↗

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