Article
Inhibition of AP-1 transcription factor causes blockade of multiple signal transduction pathways and inhibits breast cancer growth.
Oncogene - 31 Oct 2002
Liu Yongmin, Ludes-Meyers John, Zhang Yun, Munoz-Medellin Debbie, Kim Hee-Tae, Lu Chunhua, Ge Gouqing, Schiff Rachel, Hilsenbeck Susan G, Osborne C Kent, Brown Powel H
Abstract excerpt
AP-1 transcription factors play a critical role in signal transduction pathways in many cells. We have investigated the role of AP-1 in controlling proliferative signals in breast cells, and have previously shown that AP-1 complexes are activated by peptide and steroid growth factors in both normal and malignant breast cells. In this study, we investigated the role of AP-1 in transducing proliferative signals...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.