Article
Mechanism of action of a dominant negative c-jun mutant in inhibiting activator protein-1 activation.
Molecular carcinogenesis - 1 Dec 2002
Thompson Eric J, Gupta Ashok, Stratton M Suzanne, Bowden G Tim
Abstract excerpt
The dominant negative c-jun TAM-67 has been shown to inhibit tumor promotion induced by 12-O-tetradecanoylphorbol-13-acetate and okadaic acid (OA). To better understand this phenomenon, we investigated the mechanism of action of TAM-67 in response to OA. To identify the mechanism of action, we used a 6xHis-tagged TAM-67 as well as chimeric constructs of TAM-67 that either cannot bind DNA or cannot heterodimerize...
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