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Article

Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity.

Aging cell - 1 Dec 2012

Zhao Ling, Yang Fan, Xu Ke, Cao Huiqing, Zheng Gu-Yan, Zhang Yan, Li Jianxin, Cui Hanbin, Chen Xiaomin, Zhu Zhiming, He Hongbo, Mo Xianming, Kennedy Brian K, Suh Yousin, Zeng Yi, Tian Xiao-Li

Abstract excerpt

β-adrenoceptors are the common pharmacological targets for the treatment of cardiovascular diseases and asthma. Genetic modifications of β-adrenergic system in engineered mice affect their lifespan. Here, we tested whether genes encoding for key components of the β-adrenergic signaling pathway are associated with human longevity. We performed a 10-year follow-up study of the Chinese longitudinal healthy longevity...

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Source

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Identifiers

PMID: 23020224
DOI: 10.1111/acel.12011
PMCID: PMC3633790

Genes

ADRB2
ADCY5
ADCY6
ADRB1
MAPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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