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Article

BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.

The Journal of biological chemistry - 2 Sept 2005

Fotinopoulou Angeliki, Tsachaki Maria, Vlavaki Maria, Poulopoulos Alexandros, Rostagno Agueda, Frangione Blas, Ghiso Jorge, Efthimiopoulos Spiros

Abstract excerpt

Transmembrane proteins BRI2 and amyloid precursor protein (APP) co-localize with amyloid beta (Abeta) lesions in sporadic Alzheimer disease and mutations in both precursor proteins are linked to early-onset familial cases of cerebral amyloidosis associated with dementia and/or cerebral hemorrhage. A specific interaction between BRI2 and APP was unveiled by immunoprecipitation experiments using transfected and...

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Identifiers

PMID: 16027166
DOI: 10.1074/jbc.C500231200

Genes

APP

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BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.PMID 16027166Read ↗

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