Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amyloid and intracellular accumulation of BRI2.

Neurobiology of aging - 1 Apr 2017

Garringer Holly J, Sammeta Neeraja, Oblak Adrian, Ghetti Bernardino, Vidal Ruben

Abstract excerpt

Familial British dementia (FBD) and familial Danish dementia (FDD) are caused by mutations in the BRI2 gene. These diseases are characterized clinically by progressive dementia and ataxia and neuropathologically by amyloid deposits and neurofibrillary tangles. Herein, we investigate BRI2 protein accumulation in FBD, FDD, Alzheimer disease and Gerstmann-Sträussler-Scheinker disease. In FBD and FDD, we observed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid Neuropathies, Familial
Share to Amyloidogenic Proteins
Share to Cataract

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebellar Ataxia

Share to Dementia

Share to Gerstmann-Straussler-Scheinker Disease

Share to Neurites

Share to Neuroglia

Source

Open in PubMed Open full text

Identifiers

PMID: 28131015
DOI: 10.1016/j.neurobiolaging.2016.12.018
PMCID: PMC5359036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amyloid and intracellular accumulation of BRI2.PMID 28131015Read ↗

Role of BRI2 in dementia.Semantic proximity Read ↗

BRI2 as a central protein involved in neurodegeneration.Semantic proximity Read ↗

The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.Semantic proximity Read ↗

Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides.Semantic proximity Read ↗

Danish and British dementia ITM2b/BRI2 mutations reduce BRI2 protein stability and impair glutamatergic synaptic transmission.Semantic proximity Read ↗

Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.Semantic proximity Read ↗

Axonal transport of British and Danish amyloid peptides via secretory vesicles.Semantic proximity Read ↗

BRI2 and BRI3 are functionally distinct phosphoproteins.Semantic proximity Read ↗

Memory Deficits Due to Familial British Dementia<i>BRI2</i>Mutation Are Caused by Loss of<i>BRI2</i>Function Rather than AmyloidosisSemantic proximity Read ↗

Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2.Semantic proximity Read ↗

BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.Semantic proximity Read ↗

Microglia produce the amyloidogenic ABri peptide in familial British dementiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.