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Article

APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant.

The EMBO journal - 17 May 2011

Tamayev Robert, Matsuda Shuji, Giliberto Luca, Arancio Ottavio, D'Adamio Luciano

Abstract excerpt

An autosomal dominant mutation in the BRI2/ITM2B gene causes familial Danish dementia (FDD). Analysis of FDD(KI) mice, a mouse model of FDD genetically congruous to the human disease since they carry one mutant and one wild-type Bri2/Itm2b allele, has shown that the Danish mutation causes loss of Bri2 protein, synaptic plasticity and memory impairments. BRI2 is a physiological interactor of Aβ-precursor protein...

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Source

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Identifiers

PMID: 21587206
DOI: 10.1038/emboj.2011.161
PMCID: PMC3116289

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant.PMID 21587206Read ↗

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Memory Deficits Due to Familial British Dementia<i>BRI2</i>Mutation Are Caused by Loss of<i>BRI2</i>Function Rather than AmyloidosisSemantic proximity Read ↗

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