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Article

BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Aug 2008

Matsuda Shuji, Giliberto Luca, Matsuda Yukiko, McGowan Eileen M, D'Adamio Luciano

Abstract excerpt

Genetic alterations of amyloid beta-peptide (Abeta) production caused by mutations in the Abeta precursor protein (APP) cause familial Alzheimer's disease (AD). Mutations in BRI2, a gene of undefined function, are linked to familial British and Danish dementias, which are pathologically and clinically similar to Alzheimer's disease. We report that BRI2 is a physiological suppressor of Abeta production. BRI2...

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Share to Adaptor Proteins, Signal Transducing
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Amyloid Precursor Protein Secretases

Share to Enzyme Inhibitors

Share to Enzyme-Linked Immunosorbent Assay

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Source

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Identifiers

PMID: 18753367
DOI: 10.1523/JNEUROSCI.2094-08.2008
PMCID: PMC3844774

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.PMID 18753367Read ↗

BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.Semantic proximity Read ↗

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BRI2 (ITM2b) inhibits Abeta deposition in vivo.Semantic proximity Read ↗

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BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer’s disease and related dementiasSemantic proximity Read ↗

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