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Article

BRI2 as a central protein involved in neurodegeneration.

Biotechnology journal - 1 Dec 2008

Tsachaki Maria, Ghiso Jorge, Efthimiopoulos Spiros

Abstract excerpt

BRI2 is a protein that when mutated causes familial British and familial Danish dementias. Upon cleavage, the mutated BRI2 proteins release the peptides ABri and ADan, which are amyloidogenic and accumulate in the brains of patients. Although BRI2 has an unknown function, several reports indicate...

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Source

Identifiers

PMID: 19072909
DOI: 10.1002/biot.200800247

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19072909-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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BRI2 as a central protein involved in neurodegeneration.PMID 19072909Read ↗

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Danish and British dementia ITM2b/BRI2 mutations reduce BRI2 protein stability and impair glutamatergic synaptic transmission.Semantic proximity Read ↗

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Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides.Semantic proximity Read ↗

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