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Article

8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis.

Cancer research - 15 Jul 2005

Kunisada Makoto, Sakumi Kunihiko, Tominaga Yohei, Budiyanto Arief, Ueda Masato, Ichihashi Masamitsu, Nakabeppu Yusaku, Nishigori Chikako

Abstract excerpt

8-Oxoguanine is one of the oxidative DNA damages that can result in stable mutations. The Ogg1 gene encodes the repair enzyme 8-oxoguanine-DNA glycosylase, which removes the oxidized base from DNA. In this study, we investigated the role of 8-oxoguanine in skin carcinogenesis induced by UVB irradiation using Ogg1 knockout mice (C57Bl/6J background). We examined the effect of UVB irradiation on the formation of...

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Identifiers

PMID: 16024598
DOI: 10.1158/0008-5472.CAN-05-0724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis.PMID 16024598Read ↗

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