Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased ROS generation in subsets of OGG1 knockout fibroblast cells.

Mechanisms of ageing and development - 1 Jan 2000

Bacsi Attila, Chodaczek Grzegorz, Hazra Tapas K, Konkel David, Boldogh Istvan

Abstract excerpt

Oxoguanine DNA glycosylase (OGG1) is a major base excision repair protein responsible for excision of the mutagenic 8-oxoguanosine (8-oxoG) lesions from the genome. Despite OGG1's importance, the moderate phenotype of Ogg1-null (Ogg1(-/-)) mice is not well understood. This study addresses a mechanism by which Ogg1(-/-) cells limit accumulation of 8-oxoG in their genome. Our data reveal that a subset of Ogg1(-/-)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to DNA Glycosylases
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Guanosine

Share to Hydrogen Peroxide

Share to Mitochondria

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 18006041
DOI: 10.1016/j.mad.2007.09.005
PMCID: PMC2704552

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased ROS generation in subsets of OGG1 knockout fibroblast cells.PMID 18006041Read ↗

Drosophila Ogg1 is required to suppress 8-oxo-guanine accumulation following oxidative stress.Semantic proximity Read ↗

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage.Semantic proximity Read ↗

Oxidative DNA damage in the in utero initiation of postnatal neurodevelopmental deficits by normal fetal and ethanol-enhanced oxidative stress in oxoguanine glycosylase 1 knockout mice.Semantic proximity Read ↗

Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells.Semantic proximity Read ↗

8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis.Semantic proximity Read ↗

High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress.Semantic proximity Read ↗

Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice.Semantic proximity Read ↗

No major role for 7,8-dihydro-8-oxoguanine in ultraviolet light-induced mutagenesis.Semantic proximity Read ↗

Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence.Semantic proximity Read ↗

OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culture†.Semantic proximity Read ↗

Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.Semantic proximity Read ↗

Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.