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Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype.

Mutagenesis - 1 Nov 2012

Yogianti Flandiana, Kunisada Makoto, Ono Ryusuke, Sakumi Kunihiko, Nakabeppu Yusaku, Nishigori Chikako

Abstract excerpt

Different wavelengths of ultraviolet (UV) light have different promoting effects on skin carcinogenesis. Narrowband UVB (NB-UVB) has a single-peak wavelength of 311 nm and is widely used for treating skin diseases. Our previous work showed that, in comparison with conventional broadband UVB (BB-UVB), long-term exposure to NB-UVB induces higher frequency of skin cancer in mice, and it suggested that this is...

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PMID: 22844076
DOI: 10.1093/mutage/ges029

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