Article

Lifespan of male and female APP/PS1 and APP <sup>NL-F/NL-F</sup> mouse models of Alzheimer’s disease

2024-10-18

Abstract excerpt

Alzheimer’s disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP NL-F/NL-F ) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between within genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased a...

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Literature Corpus work: 9dd1aa81-ab11-5b08-ac5b-684f83c09a48
DOI: 10.1101/2024.10.15.618508

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