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Reduced p75 NTR expression delays disease onset only in female mice of a transgenic model of familial amyotrophic lateral sclerosis

1 Jun 2003

Abstract excerpt

hSOD1 (G93A) transgenic mice develop pathological changes similar to those in patients with familial amyotrophic lateral sclerosis (FALS). In particular, the progressive degeneration of motoneurons is charactered in this mouse model. One feature of stressed motoneurons in ALS and the hSOD1 mice is the induction of the p75 neurotrophin receptor, which is thought, under certain circumstances, to be a...

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PMID: 14506941
DOI: 10.1080/14660820301185

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