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Article

Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions.

Neurobiology of disease - 1 Dec 2005

Chee Francis C, Mudher Amritpal, Cuttle Matthew F, Newman Tracey A, MacKay Daniel, Lovestone Simon, Shepherd David

Abstract excerpt

We have shown that over-expression of human tau (0N3R) in Drosophila larval motor neurons causes significant morphological and functional disruption to the neuromuscular junctions (NMJs). Tau-expressing NMJs are reduced in size with irregular and abnormal bouton structure. Immunocytochemical analysis shows that the abnormal NMJs still retain synaptotagmin expression and form active zones. Functionally, the NMJs...

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Identifiers

PMID: 16023860
DOI: 10.1016/j.nbd.2005.05.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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