Article
Tau association with synaptic vesicles causes presynaptic dysfunction.
Nature communications - 11 May 2017
Zhou Lujia, McInnes Joseph, Wierda Keimpe, Holt Matthew, Herrmann Abigail G, Jackson Rosemary J, Wang Yu-Chun, Swerts Jef, Beyens Jelle, Miskiewicz Katarzyna, Vilain Sven, Dewachter Ilse, Moechars Diederik, De Strooper Bart, Spires-Jones Tara L, De Wit Joris, Verstreken Patrik
Abstract excerpt
Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer's disease. Under pathological conditions, Tau dissociates from axonal microtubules and missorts to pre- and postsynaptic terminals. Patients suffer from early synaptic dysfunction prior to Tau aggregate formation, but the underlying mechanism is unclear. Here we show that pathogenic Tau binds to synaptic vesicles via its N-terminal...
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