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Article

Overexpression of an ALS-associated FUS mutation in C. elegans disrupts NMJ morphology and leads to defective neuromuscular transmission.

Biology open - 7 Dec 2020

Markert Sebastian M, Skoruppa Michael, Yu Bin, Mulcahy Ben, Zhen Mei, Gao Shangbang, Sendtner Michael, Stigloher Christian

Abstract excerpt

The amyotrophic lateral sclerosis (ALS) neurodegenerative disorder has been associated with multiple genetic lesions, including mutations in the gene for fused in sarcoma (FUS), a nuclear-localized RNA/DNA-binding protein. Neuronal expression of the pathological form of FUS proteins in Caenorhabditis elegans results in mislocalization and aggregation of FUS in the cytoplasm, and leads to impairment of motility....

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Identifiers

PMID: 33148607
DOI: 10.1242/bio.055129
PMCID: PMC7746668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Overexpression of an ALS-associated FUS mutation in C. elegans disrupts NMJ morphology and leads to defective neuromuscular transmission.PMID 33148607Read ↗

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