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Article

The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses.

Neuron - 4 Aug 2005

Guo Xiufang, Macleod Greg T, Wellington Andrea, Hu Fangle, Panchumarthi Sarvari, Schoenfield Miriam, Marin Leo, Charlton Milton P, Atwood Harold L, Zinsmaier Konrad E

Abstract excerpt

We have identified EMS-induced mutations in Drosophila Miro (dMiro), an atypical mitochondrial GTPase that is orthologous to human Miro (hMiro). Mutant dmiro animals exhibit defects in locomotion and die prematurely. Mitochondria in dmiro mutant muscles and neurons are abnormally distributed. Instead of being transported into axons and dendrites, mitochondria accumulate in parallel rows in neuronal somata. Mutant...

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Source

Identifiers

PMID: 16055062
DOI: 10.1016/j.neuron.2005.06.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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