Article

An ALS-associated mutation in human FUS reduces neurotransmission from <i>C. elegans</i> motor neurons to muscles

2019-11-30

Abstract excerpt

Amytrophic lateral sclerosis (ALS) is a neurodegenerative disorder that has been associated with multiple genetic lesions, including mutations in the gene FUS (Fused in Sarcoma), an RNA/DNA-binding protein. Expression of the ALS-associated human FUS in C. elegans results in mislocalization and aggregation of FUS outside the nucleus, and leads to impaired neuromuscular behaviors. However, the mechanisms by which m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b9bc28b-1d75-540c-a991-1ea79cf5d35d
DOI: 10.1101/860536

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An ALS-associated mutation in human FUS reduces neurotransmission from <i>C. elegans</i> motor neurons to musclesDOI 10.1101/860536Read

Overexpression of an ALS-associated FUS mutation in C. elegans disrupts NMJ morphology and leads to defective neuromuscular transmission.Semantic proximity Read

ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism.Semantic proximity Read

Mitochondrial abnormalities and disruption of the neuromuscular junction precede the clinical phenotype and motor neuron loss in hFUSWT transgenic miceSemantic proximity Read

Identification of a Novel Interaction of FUS and Syntaphilin May Explain Synaptic and Mitochondrial Abnormalities Caused by ALS MutationsSemantic proximity Read

Defects in Synapse Structure and Function Precede Motor Neuron Degeneration in<i>Drosophila</i>Models of FUS-Related ALSSemantic proximity Read

Autophagy induction mitigates FUS aggregate formation and early synaptic dysfunction at the NMJ in the FUS-ALS modelSemantic proximity Read

Disrupted Autophagy and Neuronal Dysfunction in <i>C. elegans</i> Knock-in Models of FUS Amyotrophic Lateral SclerosisSemantic proximity Read

Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations.Semantic proximity Read

Innervation and cargo-specific axonal transport impairments in FUS-ALS mice with gain and loss of functionSemantic proximity Read

Mutations in FUS lead to synaptic dysregulation in ALS-iPSC derived neurons.Semantic proximity Read

The ALS gene FUS regulates synaptic transmission at the Drosophila neuromuscular junction.Semantic proximity Read

Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS miceSemantic proximity Read