Article

Fragile X Premutation rCGG Repeats Impairs Synaptic Growth and Synaptic Transmission at <i>Drosophila</i> larval Neuromuscular Junction

2020-10-22

Abstract excerpt

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a progressive neurodegenerative disease manifesting in the premutation (PM) carriers of the FMR1 gene with alleles bearing 55-200 CGG repeats. The discovery of a broad spectrum of clinical and cell developmental abnormalities among PM carriers with or without FXTAS, and in model systems suggests that neurodegeneration seen in FXTAS could be the inevitable end...

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Literature Corpus work: e428aa4a-2bcf-53e1-ac27-43ae5f8df45e
DOI: 10.1101/2020.10.22.349928

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