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Article

Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study.

Journal of the neurological sciences - 15 Sept 2005

Myllykangas Liisa, Wavrant-De Vrièze Fabienne, Polvikoski Tuomo, Notkola Irma-Leena, Sulkava Raimo, Niinistö Leena, Edland Steven D, Arepalli Sampath, Adighibe Omanma, Compton Danielle, Hardy John, Haltia Matti, Tienari Pentti J

Abstract excerpt

Genetic linkage studies have provided evidence for a late-onset Alzheimer's disease (AD) susceptibility locus on chromosome 21q. We have tested, in a two-stage association study, whether allelic or haplotype variation of the beta-amyloid cleaving enzyme-2 (BACE2) locus on chromosome 21q affects the risk of late-onset AD. In stage-1, an unselected population-based sample of Finns aged 85 years or over (n=515) was...

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Source

Identifiers

PMID: 16023140
DOI: 10.1016/j.jns.2005.04.008

Genes

BACE2
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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