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Article

Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 May 2003

Gold Gabriel, Blouin Jean-Louis, Herrmann François R, Michon Agnès, Mulligan Reinhild, Duriaux Saïl Geneviève, Bouras Constantin, Giannakopoulos Panteleimon, Antonarakis Stylianos E

Abstract excerpt

Alzheimer disease (AD) is characterized neuropathologically by neurofibrillary tangles and senile plaques. A key component of plaques is A beta, a polypeptide derived from A beta-precursor protein (APP) through proteolytic cleavage catalyzed by beta and gamma-secretase. We hypothesized that sequence variation in genes BACE1 (on chromosome 11q23.3) and BACE2 (on chromosome 21q22.3), which encode two closely...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12707937
DOI: 10.1002/ajmg.b.10010

Genes

BACE1
APOE
BACE2
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers.PMID 12707937Read ↗

Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer’s Disease and CSF Amyloid Biomarkers in APOE ε4 Non-CarriersSemantic proximity Read ↗

Association studies using novel polymorphisms in BACE1 and BACE2.Semantic proximity Read ↗

Polymorphism in the BACE gene influences the risk for Alzheimer's disease.Semantic proximity Read ↗

BACE1 gene promoter single-nucleotide polymorphisms in Alzheimer's disease.Semantic proximity Read ↗

BACE1 polymorphisms do not influence platelet membrane beta-secretase activity or genetic susceptibility for Alzheimer's disease in the Northern Irish population.Semantic proximity Read ↗

Association of BACE1 gene polymorphism with Alzheimer's disease in Asian populations: meta-analysis including Korean samples.Semantic proximity Read ↗

Lack of evidence to support the association of polymorphisms within the alpha- and beta-secretase genes (ADAM10/BACE1) with Alzheimer's disease.Semantic proximity Read ↗

A common BACE1 polymorphism is a risk factor for sporadic Creutzfeldt-Jakob disease.Semantic proximity Read ↗

Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease.Semantic proximity Read ↗

Association study between Alzheimer's disease and genes involved in Abeta biosynthesis, aggregation and degradation: suggestive results with BACE1.Semantic proximity Read ↗

Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease.Semantic proximity Read ↗

Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease.Semantic proximity Read ↗

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