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Article

Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson.

Biochimica et biophysica acta - 1 Oct 2008

Zabrocki Piotr, Bastiaens Ilse, Delay Charlotte, Bammens Tine, Ghillebert Ruben, Pellens Klaartje, De Virgilio Claudio, Van Leuven Fred, Winderickx Joris

Abstract excerpt

Parkinson's disease is a neurodegenerative disorder characterized by the formation of Lewy bodies containing aggregated alpha-synuclein. We used a yeast model to screen for deletion mutants with mislocalization and enhanced inclusion formation of alpha-synuclein. Many of the mutants were affected in functions related to vesicular traffic but especially mutants in endocytosis and vacuolar degradation combined...

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PMID: 18634833
DOI: 10.1016/j.bbamcr.2008.06.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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