Article
The type-1 insulin-like growth factor receptor tyrosine kinase and breast cancer: biology and therapeutic relevance.
Cancer metastasis reviews - 1 Dec 2003
Gross Jennifer M, Yee Douglas
Abstract excerpt
The development of the mammary gland requires the coordinated expression of hormones and growth factors. Likewise, some transformed breast cells continue to respond to these same extracellular signals. Thus, understanding the mechanisms that control normal development of tissues can lead to new therapeutic targets. The insulin-like growth factor (IGF) system plays an important role in the normal development and...
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