Article
Broad copy neutral-loss of heterozygosity regions and rare recurring copy number abnormalities in normal karyotype-acute myeloid leukemia genomes.
Genes, chromosomes & cancer - 1 Nov 2010
Barresi Vincenza, Romano Alessandra, Musso Nicolò, Capizzi Carmela, Consoli Carla, Martelli Maria Paola, Palumbo Giuseppe, Di Raimondo Francesco, Condorelli Daniele F
Abstract excerpt
We analyzed, by the latest high-resolution SNP arrays, 19 Normal Karyotype (NK)-AML patients at diagnosis (Dx) and remission (R) phases, to determine the number of tumor-associated copy number abnormalities (CNAs) and copy neutral-loss of heterozygosity (CN-LOH) regions per patient and to identify possible recurring genomic abnormalities. The number of tumor-associated CNAs was determined after comparison of...
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