A low rate of loss of heterozygosity is found at many different loci in childhood B-lineage acute lymphocytic leukemia.

Article

A low rate of loss of heterozygosity is found at many different loci in childhood B-lineage acute lymphocytic leukemia.

Leukemia - 1 Sept 1996

Cavé H, Guidal C, Elion J, Vilmer E, Grandchamp B

Abstract excerpt

We have carried out a screening for loss of heterozygosity (LOH) in 51 children with B-lineage acute lymphoblastic leukemia (ALL). Forty-six highly polymorphic microsatellite markers located in subtelomeric areas of every chromosome arm were analyzed in each patient. Allelic losses were encounter...

Topics

Alleles
Burkitt Lymphoma
Child
Chromosome Aberrations
DNA, Neoplasm
DNA, Satellite
Diploidy
Gene Deletion
Genetic Markers
Heterozygote
Humans
Karyotyping
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Telomere

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