Article
Allelic loss at 16q23.2 is associated with good prognosis in high grade prostate cancer.
The Prostate - 1 Dec 2005
Fromont Gaëlle, Valeri Antoine, Cher Michael, Pontes Jose Edson, Vallancien Guy, Validire Pierre, Latil Alain, Cussenot Olivier
Abstract excerpt
PURPOSE: Loss of heterozygosity (LOH) at 16q23.2 is an early and frequent event in prostate cancer. LOH is thought to be involved in tumor development and progression mainly through inactivation of tumor suppressor genes. However, it has been demonstrated that LOH at 16q23.2 is an independent marker of good prognosis in breast cancer. In the present study, we evaluated the clinical relevance of 16q23.2 LOH in...
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