Article
Loss of heterozygosity at the BRCA2 locus detected by multiplex ligation-dependent probe amplification is common in prostate cancers from men with a germline BRCA2 mutation.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2008
Willems Amber J, Dawson Sarah-Jane, Samaratunga Hema, De Luca Alessandro, Antill Yoland C, Hopper John L, Thorne Heather J
Abstract excerpt
PURPOSE: Prostate cancer risk is increased for men carrying a pathogenic germline mutation in BRCA2, and perhaps BRCA1. Our primary aim was to test for loss of heterozygosity (LOH) at the locus of the mutation in prostate cancers from men who a carry pathogenic germline mutation in BRCA1 or BRCA2...
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