Article
ATM mutations in B-cell chronic lymphocytic leukemia.
Cancer research - 1 Jan 1999
Bullrich F, Rasio D, Kitada S, Starostik P, Kipps T, Keating M, Albitar M, Reed J C, Croce C M
Abstract excerpt
Mutations in the ATM gene located on the long arm of chromosome 11 at 11q22-23 cause ataxia-telangiectasia, an autosomal recessive disorder that is associated with increased incidence of malignancy and, particularly, lymphoid tumors. A role for ATM in the development of sporadic T-cell chronic le...
Topics
- Adult
- Ataxia Telangiectasia Mutated Proteins
- Base Sequence
- Cell Cycle Proteins
- Chromosomes, Human, Pair 11
- DNA-Binding Proteins
- Exons
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Molecular Sequence Data
- Mutation
- Protein Serine-Threonine Kinases
- Proteins
- Sequence Analysis, DNA
- Tumor Suppressor Proteins