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Article

Prognostic significance of ATM mutations in chronic lymphocytic leukemia: A meta-analysis.

Leukemia research - 1 Dec 2021

Baghaei Vaji Farnaz, Boroumand Nasr Arash, Rezvani Ali, Ayatollahi Hossein, Goudarzi Sajad, Lavasani Soroush, Bagheri Ramin

Abstract excerpt

BACKGROUND: The ATM protein acts as an essential part of the signal transduction pathway upstream of p53 which activates following induction of DNA double-strand breaks (DSBs) and leads to transcriptional proapoptotic genes activation that synchronizes DNA repair. AIM: Several studies have assessed the relationship between ATM mutations and the clinical prognosis in patients with chronic lymphocytic leukemia...

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PMID: 34735935
DOI: 10.1016/j.leukres.2021.106729

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