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Article

Mutated p53 protein expression and proliferative activity in advanced gastric cancer.

Hepato-gastroenterology - 1 Jan 2000

Ikeguchi M, Saito H, Kondo A, Tsujitani S, Maeta M, Kaibara N

Abstract excerpt

BACKGROUND/AIMS: When the DNA of cells is damaged, wild-type p53 protein induces the expression of p21 (Waf1/Cip1/Sdi1), and regulates the progression of the cell cycle by inducing G1 arrest. Thus, wild type p53 or p21 protein negatively regulates cancer cell proliferation. However, in tumor with loss of expression of functional wild-type p53 protein by mutation or allelic deletion of the gene for p53, whether...

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Identifiers

PMID: 10522058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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