Article
p21WAF1 immunohistochemical expression in breast carcinoma: correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival.
British journal of cancer - 1 Jul 1996
Barbareschi M, Caffo O, Doglioni C, Fina P, Marchetti A, Buttitta F, Leek R, Morelli L, Leonardi E, Bevilacqua G, Dalla Palma P, Harris A L
Abstract excerpt
p21 protein (p21) inhibitor of cyclin-dependent kinases is a critical downstream effector in the p53-specific pathway of growth control. p21 can also be induced by p53-independent pathways in relation to terminal differentiation. We investigated p21 immunoreactivity in normal breast and in 91 bre...
Topics
- Breast Neoplasms
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Disease-Free Survival
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Ki-67 Antigen
- Multivariate Analysis
- Mutation
- Neoplasm Proteins
- Nuclear Proteins