Article
Gene inactivation of Pf11-1 of Plasmodium falciparum by chromosome breakage and healing: identification of a gametocyte-specific protein with a potential role in gametogenesis.
The EMBO journal - 1 Jun 1992
Scherf A, Carter R, Petersen C, Alano P, Nelson R, Aikawa M, Mattei D, Pereira da Silva L, Leech J
Abstract excerpt
We report the identification of the product of the Plasmodium falciparum Pf11-1 gene and demonstrate that it is a gametocyte-specific protein that has a potential role in the rupture of the host erythrocyte and emergence of the gametes (gametogenesis). The Pf11-1 gene is a large locus (30 kb) whose sequence predicts a glutamic acid-rich polypeptide. Our identification of the Pf11-1 gene product as gametocyte...
Topics
- Animals
- Antibodies, Monoclonal
- Base Sequence
- Chromosome Aberrations
- Chromosome Deletion
- Chromosome Disorders
- Chromosome Mapping
- Chromosomes
- Cloning, Molecular
- DNA