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An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites

9 Apr 2020

Abstract excerpt

Abstract Gametocytes differentiation to gametes (gametogenesis) within mosquitos is essential for malaria parasite transmission. Both reduction in temperature and mosquito-derived XA or elevated pH are required for triggering cGMP/PKG dependent gametogenesis. However, the parasite molecule for sensing or transducing these environmental signals to initiate gametogenesis remains unknown. Here we perform a...

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PMID: 32273496
DOI: 10.1038/s41467-020-15479-3

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