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Article

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission-blocking target.

FEBS letters - 1 Jan 2026

Huppertz Frederik, Caturelli Milagros Siebeck, Lehmann Lina S, Kurth Florian, Maier Alexander G, Matuschewski Kai

Abstract excerpt

Transmission of Plasmodium parasites to Anopheles mosquitoes relies on rapid activation of mature gametocytes in the midgut, triggered by a temperature drop and xanthurenic acid. In Plasmodium yoelii, the gametogenesis essential protein 1 (GEP1) was linked to xanthurenic acid (XA)-dependent gamete activation. We characterized GEP1 in Plasmodium falciparum using CRISPR-Cas9 to create PfGEP1 loss-of-function lines....

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Identifiers

PMID: 41084330
DOI: 10.1002/1873-3468.70184
PMCID: PMC12834003

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