Article
Aberrant transcription and the failure of Plasmodium falciparum to differentiate into gametocytes.
Molecular and biochemical parasitology - 1 Nov 1994
Pologe L G
Abstract excerpt
In the human malaria parasite, Plasmodium falciparum, a DNA rearrangement is associated with erroneous transcription of the early gametocyte antigen gene, Pfg27/25, and the failure of the blood stages to differentiate into gametocytes. Altered blood stage-specific patterns of mRNA accumulation were observed for the Pfg27/25 gene, in mutant P. falciparum parasites that have lost the capacity to differentiate...
Topics
- Animals
- Antigens, Protozoan
- Base Sequence
- DNA Probes
- DNA, Protozoan
- Female
- Gene Rearrangement
- Genes, Protozoan
- Humans
- Malaria, Falciparum
- Male
- Molecular Sequence Data