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Article

Transposon mutagenesis identifies genes essential for Plasmodium falciparum gametocytogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2013

Ikadai Hiromi, Shaw Saliba Kathryn, Kanzok Stefan M, McLean Kyle J, Tanaka Takeshi Q, Cao Jun, Williamson Kim C, Jacobs-Lorena Marcelo

Abstract excerpt

Gametocytes are essential for Plasmodium transmission, but little is known about the mechanisms that lead to their formation. Using piggyBac transposon-mediated insertional mutagenesis, we screened for parasites that no longer form mature gametocytes, which led to the isolation of 29 clones (insertional gametocyte-deficient mutants) that fail to form mature gametocytes. Additional analysis revealed 16 genes...

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Identifiers

PMID: 23572579
DOI: 10.1073/pnas.1217712110
PMCID: PMC3645567

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Source receipt: pubmed, retrieved 7 Sept 2026.

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