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Article

The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo.

Genes & development - 1 Sept 2013

Hamard Pierre-Jacques, Barthelery Nicolas, Hogstad Brandon, Mungamuri Sathish Kumar, Tonnessen Crystal A, Carvajal Luis A, Senturk Emir, Gillespie Virginia, Aaronson Stuart A, Merad Miriam, Manfredi James J

Abstract excerpt

The p53 tumor suppressor is a transcription factor that mediates varied cellular responses. The C terminus of p53 is subjected to multiple and diverse post-translational modifications. An attractive hypothesis is that differing sets of combinatorial modifications therein determine distinct cellular outcomes. To address this in vivo, a Trp53(ΔCTD/ΔCTD) mouse was generated in which the endogenous p53 is targeted...

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Identifiers

PMID: 24013501
DOI: 10.1101/gad.224386.113
PMCID: PMC3778241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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