Article
P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1.
Neurobiology of disease - 1 Dec 2005
Mirnics Zeljka Korade, Yan Chaohua, Portugal Carmel, Kim Tae-Wan, Saragovi H Uri, Sisodia Sangram S, Mirnics Karoly, Schor Nina F
Abstract excerpt
Our recent transcriptome profiling studies suggest that presenilin 1 (PS1) regulates expression of neural cell adhesion molecule (Ncam1) through p75 neurotrophin receptor. To better understand regulation of Ncam1 transcript and protein levels by p75, we performed a series of in vitro and in vivo experiments. The combined results suggest that p75 receptor is required for both resting and NGF-induced Ncam1...
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