Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between Presenilin-1 and TRAF6 modulates regulated intramembrane proteolysis of the p75NTR neurotrophin receptor.

Journal of neurochemistry - 1 Jan 2009

Powell James C, Twomey Ciara, Jain Raunak, McCarthy Justin V

Abstract excerpt

The p75 neurotrophin receptor (p75(NTR)) is a member of the tumour necrosis factor superfamily, which relies on the recruitment of cytosolic protein partners including the tumour necrosis factor receptor-associated factor 6 (TRAF6) E3 ubiquitin ligase to produce cellular responses. Recently, p75(NTR) was also shown to undergo presenilin-dependent, gamma-secretase-mediated regulated intramembrane proteolysis. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Densitometry
Share to Glutamic Acid
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Presenilin-1

Share to Proline

Share to Receptor, Nerve Growth Factor

Share to TNF Receptor-Associated Factor 6

Share to Ubiquitination

Source

Identifiers

PMID: 19012753
DOI: 10.1111/j.1471-4159.2008.05763.x

Genes

TRAF6
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between Presenilin-1 and TRAF6 modulates regulated intramembrane proteolysis of the p75NTR neurotrophin receptor.PMID 19012753Read ↗

A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains.Semantic proximity Read ↗

Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin.Semantic proximity Read ↗

Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains.Semantic proximity Read ↗

TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brainsSemantic proximity Read ↗

Familial Alzheimer's disease presenilin 1 mutation M146V increases gamma secretase cutting of p75NTR in vitro.Semantic proximity Read ↗

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis.Semantic proximity Read ↗

Structural Basis of p75 Transmembrane Domain Dimerization.Semantic proximity Read ↗

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.Semantic proximity Read ↗

P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1.Semantic proximity Read ↗

Secretion of the Notch-1 Abeta-like peptide during Notch signaling.Semantic proximity Read ↗

Presenilins: molecular switches between proteolysis and signal transductionSemantic proximity Read ↗

Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.