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Article

Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Jun 2007

Lazarov Orly, Morfini Gerardo A, Pigino Gustavo, Gadadhar Archana, Chen Xiangjun, Robinson John, Ho Hanson, Brady Scott T, Sisodia Sangram S

Abstract excerpt

Presenilins (PS) play a central role in gamma-secretase-mediated processing of beta-amyloid precursor protein (APP) and numerous type I transmembrane proteins. Expression of mutant PS1 variants causes familial forms of Alzheimer's disease (FAD). In cultured mammalian cells that express FAD-linked PS1 variants, the intracellular trafficking of several type 1 membrane proteins is altered. We now report that the...

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Identifiers

PMID: 17596450
DOI: 10.1523/JNEUROSCI.4272-06.2007
PMCID: PMC2801050

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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