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Article

N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio.

Journal of neurochemistry - 1 Jan 2009

Uemura Kengo, Lill Christina M, Banks Mary, Asada Megumi, Aoyagi Nobuhisa, Ando Koichi, Kubota Masakazu, Kihara Takeshi, Nishimoto Takaaki, Sugimoto Hachiro, Takahashi Ryosuke, Hyman Bradley T, Shimohama Shun, Berezovska Oksana, Kinoshita Ayae

Abstract excerpt

In neurons, Presenilin 1(PS1)/gamma-secretase is located at the synapses, bound to N-cadherin. We have previously reported that N-cadherin-mediated cell-cell contact promotes cell-surface expression of PS1/gamma-secretase. We postulated that N-cadherin-mediated trafficking of PS1 might impact syn...

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Identifiers

PMID: 19046403
DOI: 10.1111/j.1471-4159.2008.05760.x
PMCID: PMC2682435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19046403-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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