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Article

Heritable factors shape natural human IgM reactivity to Ro60/SS-A and may predispose for SLE-associated IgG anti-Ro and anti-La autoantibody production.

Journal of autoimmunity - 1 Sept 2005

Ferreira Ricardo, Barreto Marta, Santos Eugénia, Pereira Clara, Martins Berta, Andreia Rita, Crespo Francisco, Viana João Faro, Vasconcelos Carlos, Ferreira Carlos, Vicente Astrid Moura, Fesel Constantin

Abstract excerpt

Systemic lupus erythematosus (SLE) is characterized by various IgG autoreactivities, among which anti-Ro/SS-A is particularly pathology-associated and early detectable. SLE also shows significant familial aggregation, but genetic factors are not well understood and remain controversial for disease-associated IgG. Here we report that IgM anti-Ro showed a uniquely high degree of heritability in a study of...

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Identifiers

PMID: 16006098
DOI: 10.1016/j.jaut.2005.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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